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080 - Trillium Therapeutics vs. ALX Oncology? The CD47 Space

CD47 expression and/or activity has been implicated in a number of diseases and disorders. A number of therapeutics that target the CD47/SIRPα axis are under preclinical and clinical investigation. These include anti-CD47 antibodies, engineered receptor decoys, anti-SIRPα antibodies and bispecific agents. These therapeutics differ in their pharmacodynamic, pharmacokinetic and toxicological properties.

CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 Moreover, CD47 overexpression may blunt the therapeutic action of monoclonal antibodies, and therefore, CD47 blockade would enhance antibody efficacy . Additional strategies to block this axis involve engineered SIRPα monomers or exosomes with SIRPα that have a high affinity for CD47 and that would similarly lower the macrophage threshold for phagocytosis and, as a result, T cell activation Therapeutic blockade of the CD47-SIRPα pathway has led to robust pre-clinical efficacy in vivo with several therapeutics in clinical development. While the clinical data of such agents in myeloid malignancies has been limited, initial data with magrolimab, a first-in-class anti-CD47 antibody, has been shown to be well-tolerated with encouraging efficacy results when combined with azacitidine Trillium Therapeutics has two lead candidates that encourage immune cells known as “macrophages” to gobble up cancer cells by blocking a protein known as CD47. However, the CD47 inhibitor To describe the relevance of CD47 in the tumor microenvironment and summarize data on anti-CD47 therapies, including its role in cutaneous T-cell lymphoma (CTCL). Recent findings .

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At Arch Oncology, we are aiming high to discover and develop new antibody therapeutics to treat patients living with cancer. We are committed to advancing antibodies with best-in-class potential.

Trillium Therapeutics Inc. LinkedIn

The decoy fusion protein approach is differentiated from competitors using monoclonal antibodies raised against About Trillium Therapeutics Trillium is an immuno-oncology company developing innovative therapies for the treatment of cancer. The Company’s two clinical programs, TTI-621 and TTI-622, target CD47, a “do not eat” signal that cancer cells frequently use to evade the immune system. CD47 is a cell surface protein in the immunoglobulin superfamily which is normally expressed at low levels in every healthy cell. It´s main physiologic function is to act as an inhibitor of phagocytosis; this occurs throughout interaction with SIRPa expressed on macrophages. Interaction between CD47 and SIRPa leads to activation of tyrosine phosphatases that inhibit myosin accumulation at the C4T is as differentiated as differentiated gets. FUND MANAGER.

The decoy fusion protein approach is differentiated from competitors using monoclonal antibodies raised against 4.
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By blocking this “don’t eat me” signal with decoy receptors, we aim to unmask tumor cells and make them visible to, and eradicated by, the immune system. BioSuperior™ Anti-CD47 Therapeutic Antibody (AVI-105) Our Company AbVision, Inc. (AVI) previously the Drug Discovery Group of BioVision Inc., is a privately held biopharmaceutical company headquartered in the San Francisco Bay Area. CD47 also known as integrin associated protein is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha. CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 Moreover, CD47 overexpression may blunt the therapeutic action of monoclonal antibodies, and therefore, CD47 blockade would enhance antibody efficacy .

ALX Oncology? The CD47 Space Races to a Pivotal Trial. Wed, 23 Dec 2020. 79. - 079 - ASH 2020 Updates ($TRIL $TGTX company developing next-generation antibody therapies focused on the tumor microenvironment with lead programs targeting CD73, CD39, IL-27 and CD47. PALO ALTO, Calif., April 09, 2021 (GLOBE NEWSWIRE) -- Scilex Holding (“Scilex”), an over 99% owned subsidiary of Sorrento Therapeutics (NASDAQ: SRNE,.
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32%64 201912ASH TG Therapeutics . CD47. TG. TherapeuticsTG-1801 CD47/CD19. CD47.

TTI-622, Trillium Therapeutics 2 Mar 2021 Internally developed fully human anti-CD47 antibody (STI-6643) 2021 (GLOBE NEWSWIRE) -- Sorrento Therapeutics, Inc. (Nasdaq: SRNE, We've developed a new approach to CD47 blockade that is designed to maximize in blocking CD47 and to realize the full potential of this therapeutic target. Corporate Profile. Forty Seven is a clinical-stage immuno-oncology company focused on developing novel checkpoint therapies to activate macrophages in the CD47 is highly expressed on myeloma cells and a potential therapeutic candidate for myeloma therapies. Flow cytometric analysis of patient bone marrow cells TG-1801 is an investigational first-in-class, bispecific anti-CD47/CD19 monoclonal antibody. It is the first therapy to target both CD19, a B-cell specific marker 13 14 Anti-mouse CD47 antibody therapeutic efficacy can be impaired by depletion of CD8+ T cells, and the induced memory T-cell mediated response can 9 Sep 2020 Pfizer places $25M bet on CD47 player Trillium Therapeutics into the emerging space of cancer immunotherapy drugs targeting CD47.
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These therapeutics differ in their pharmacodynamic, pharmacokinetic and toxicological properties. 2020-12-07 · CD47 is a protective “don’t eat me” signal that blocks the ability of certain immune cells to destroy the tumor. By blocking this “don’t eat me” signal with decoy receptors, we aim to unmask tumor cells and make them visible to, and eradicated by, the immune system. BioSuperior™ Anti-CD47 Therapeutic Antibody (AVI-105) Our Company AbVision, Inc. (AVI) previously the Drug Discovery Group of BioVision Inc., is a privately held biopharmaceutical company headquartered in the San Francisco Bay Area.

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That means that even if another company beats Trillium to market, the Trillium molecules may still be the first choice among physicians and patients. Is Trillium Therapeutics … 2021-4-10 · Anti-CD47 MAb: First patient dosed (NCT03512340) in Mar 2018: TTI-622: Trillium Therapeutics: Anti-SIRPα fusion protein: Uses IgG4 Fc instead of IgG1 Fc; phase I (NCT03530683) began in May 2018: Preclinical: TG-1801/NI-1701: Novimmune/TG Therapeutics: Anti-CD47/CD19 bispecific MAb: Effector arm (anti-CD47) and targeting arm (anti-CD19); deal NEW YORK, June 17, 2019 (GLOBE NEWSWIRE) -- TG Therapeutics, Inc. (NASDAQ: TGTX) today announced the presentation of preclinical data for TG-1801, the Company’s first-in-class anti-CD47/CD19 bispecific antibody, highlighting the synergistic effect of TG-1801 in combination with ublituximab, the Company’s anti-CD20 monoclonal antibody and umbralisib, the Company’s PI3K-delta inhibitor. Based on this key function, therapeutics targeting CD47 or its ligands thrombospondin-1 and SIRPα could have broad applications spanning reconstructive surgery, engineering of tissues and biocompatible surfaces, vascular diseases, diabetes, organ transplantation, radiation injuries, inflammatory diseases, and cancer. Strategies for targeting CD47 are becoming a hot spot for cancer therapy. The expression of CD47 is exercised by macrophages to make a distinction between “self” or “nonself.” Anti-CD47 antibodies block the interaction between macrophage signal regulatory protein-α (SIRPα) and tumor surface CD47. Current focus in immunotherapy has been targeted toward inhibiting CD47-SIRPα interaction via anti-CD47 antibodies.

Strategies for targeting CD47 are becoming a hot spot for cancer therapy.